A0A0C3PWG7 protein (Pisolithus tinctorius) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

A0A0C3PWG7

MFS domain-containing protein. (476 aa)

Predicted Functional Partners:

A0A0C3JY49

0.789

A0A0C3K858

0.613

A0A0C3JMU9

0.513

A0A0C3PAA3

0.513

A0A0C3PJ42

0.513

A0A0C3KAW1

0.511

A0A0C3P5G4

0.511

A0A0C3IM42

0.509

A0A0C3J4S0

0.509

A0A0C3NRV3

0.509

Your Current Organism:

Pisolithus tinctorius

NCBI taxonomy Id: 870435
Other names: P. tinctorius Marx 270, Pisolithus tinctorius ATCC MYA-4688, Pisolithus tinctorius Marx 270

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0C3IM42	A0A0C3J4S0	Thymidylat_synt domain-containing protein.	Thymidylat_synt domain-containing protein.	0.818
A0A0C3IM42	A0A0C3K858	Thymidylat_synt domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.468
A0A0C3IM42	A0A0C3NRV3	Thymidylat_synt domain-containing protein.	Thymidylat_synt domain-containing protein.	0.819
A0A0C3IM42	A0A0C3PWG7	Thymidylat_synt domain-containing protein.	MFS domain-containing protein.	0.509
A0A0C3J4S0	A0A0C3IM42	Thymidylat_synt domain-containing protein.	Thymidylat_synt domain-containing protein.	0.818
A0A0C3J4S0	A0A0C3K858	Thymidylat_synt domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.468
A0A0C3J4S0	A0A0C3NRV3	Thymidylat_synt domain-containing protein.	Thymidylat_synt domain-containing protein.	0.818
A0A0C3J4S0	A0A0C3PWG7	Thymidylat_synt domain-containing protein.	MFS domain-containing protein.	0.509
A0A0C3JMU9	A0A0C3JY49	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.933
A0A0C3JMU9	A0A0C3K858	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.485
A0A0C3JMU9	A0A0C3PAA3	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.815
A0A0C3JMU9	A0A0C3PJ42	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.864
A0A0C3JMU9	A0A0C3PWG7	Uncharacterized protein.	MFS domain-containing protein.	0.513
A0A0C3JY49	A0A0C3JMU9	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein.	0.933
A0A0C3JY49	A0A0C3K858	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glyceraldehyde-3-phosphate dehydrogenase.	0.591
A0A0C3JY49	A0A0C3PAA3	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.933
A0A0C3JY49	A0A0C3PJ42	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.943
A0A0C3JY49	A0A0C3PWG7	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	MFS domain-containing protein.	0.789
A0A0C3K858	A0A0C3IM42	Glyceraldehyde-3-phosphate dehydrogenase.	Thymidylat_synt domain-containing protein.	0.468
A0A0C3K858	A0A0C3J4S0	Glyceraldehyde-3-phosphate dehydrogenase.	Thymidylat_synt domain-containing protein.	0.468

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.925

expected number of edges:

12

PPI enrichment p-value:

3.47e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

9 of 10

2.5

8.01

1.26e-17

GO:0046417

Chorismate metabolic process

8 of 8

2.54

7.39

7.49e-16

GO:0009423

Chorismate biosynthetic process

7 of 7

2.54

6.39

1.43e-13

GO:0016053

Organic acid biosynthetic process

10 of 158

1.34

2.28

3.71e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 112

1.4

2.16

1.24e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004764

Shikimate 3-dehydrogenase (NADP+) activity

2 of 2

2.54

0.83

0.0304

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

2 of 4

2.24

0.78

0.0371

GO:0016835

Carbon-oxygen lyase activity

3 of 32

1.51

0.7

0.0371

GO:0016829

Lyase activity

4 of 95

1.17

0.6

0.0371

GO:0003824

Catalytic activity

11 of 1844

0.32

0.24

0.0451

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25072253

(2014) Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis.

3 of 3

2.54

1.55

0.0014

PMID:24586713

(2014) Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.

3 of 3

2.54

1.55

0.0014

PMID:35163582

(2022) Comparison of Automated Ribotyping, spa Typing, and MLST in 108 Clinical Isolates of Staphylococcus aureus from Orthopedic Infections.

3 of 4

2.42

1.54

0.0014

PMID:32391366

(2020) Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China.

3 of 5

2.32

1.52

0.0014

PMID:36873553

(2023) The effect of different C. difficile MLST strains on viability and activity of macrophages.

3 of 6

2.24

1.51

0.0014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Aromatic amino acid family biosynthetic process, and CorA, cytoplasmic domain

9 of 12

2.42

7.64

2.90e-17

CL:1322

Chorismate metabolic process

6 of 6

2.54

5.46

1.70e-11

CL:1291

Mixed, incl. Histidine biosynthetic process, and Aromatic amino acid family biosynthetic process

10 of 43

1.91

5.27

5.00e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdc00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 17

2.31

8.23

4.91e-20

pdc01230

Biosynthesis of amino acids

9 of 116

1.43

2.53

8.08e-11

pdc01110

Biosynthesis of secondary metabolites

10 of 235

1.17

1.71

3.28e-10

pdc01100

Metabolic pathways

11 of 605

0.8

0.85

4.23e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 7

2.54

6.47

9.59e-14

KW-0521

NADP

3 of 23

1.66

1.19

0.0030

KW-0456

Lyase

4 of 92

1.18

0.85

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08501

Shikimate dehydrogenase substrate binding domain

2 of 2

2.54

0.86

0.0274

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