STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SHG34430.1uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (464 aa)    
Predicted Functional Partners:
cysC
Sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
  
  
 0.998
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.995
SHG34549.1
Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.994
SHG34506.1
Sulfite reductase (NADPH) hemoprotein beta-component.
 
  
 0.990
SHH03263.1
Siroheme synthase, N-terminal domain-containing protein.
 
 
0.971
SHG25113.1
Porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.968
SHH61426.1
precorrin-6Y C5,15-methyltransferase (decarboxylating).
  
 
 0.933
SHH61322.1
Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family.
    
 0.925
SHG34469.1
Protein of unknown function.
 
    0.922
SHH61556.1
uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
0.915
Your Current Organism:
Cognatishimia maritima
NCBI taxonomy Id: 870908
Other names: C. maritima, CCUG 60021, DSM 28223, KCTC 23347, Thalassobius maritima, Thalassobius maritimus, Thalassobius maritimus Park et al. 2012, Thalassobius sp. GSW-6, Thalassobius sp. GSW-M6, strain GSW-M6
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