STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHG96457.1Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (569 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.952
SHG96278.1
Sugar lactone lactonase YvrE.
 
  
  0.940
SHH48209.1
Glutamate synthase (NADPH/NADH) large chain.
  
  
 0.889
SHG28041.1
Acetolactate synthase, large subunit.
 
 0.842
SHG96367.1
2-dehydro-3-deoxygalactonokinase.
 
     0.835
SHG96321.1
2-keto-3-deoxy-phosphogalactonate aldolase.
  
 
 0.830
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.829
SHH24769.1
D-alanine transaminase.
  
  0.824
SHG35916.1
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.820
SHG96411.1
NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.
 
     0.807
Your Current Organism:
Cognatishimia maritima
NCBI taxonomy Id: 870908
Other names: C. maritima, CCUG 60021, DSM 28223, KCTC 23347, Thalassobius maritima, Thalassobius maritimus, Thalassobius maritimus Park et al. 2012, Thalassobius sp. GSW-6, Thalassobius sp. GSW-M6, strain GSW-M6
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.