| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFM45207.1 | cobQ | HMPREF0580_2096 | HMPREF0580_0075 | FemAB family protein; Pfam: PF02388; InterPro: IPR016181. | CobB/CobQ-like protein; COG: COG3442; Pfam: PF07685; InterPro: IPR011698. | 0.882 |
| EFM45207.1 | murE | HMPREF0580_2096 | HMPREF0580_0076 | FemAB family protein; Pfam: PF02388; InterPro: IPR016181. | Mur ligase middle domain protein; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.883 |
| EFM45207.1 | murG | HMPREF0580_2096 | HMPREF0580_1315 | FemAB family protein; Pfam: PF02388; InterPro: IPR016181. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.888 |
| EFM45626.1 | murC | HMPREF0580_1715 | HMPREF0580_1316 | Hypothetical protein; 1.14.99.36. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.552 |
| EFM45626.1 | murD | HMPREF0580_1715 | HMPREF0580_1313 | Hypothetical protein; 1.14.99.36. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.697 |
| EFM45626.1 | murE | HMPREF0580_1715 | HMPREF0580_0076 | Hypothetical protein; 1.14.99.36. | Mur ligase middle domain protein; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.630 |
| EFM45626.1 | murF | HMPREF0580_1715 | HMPREF0580_1311 | Hypothetical protein; 1.14.99.36. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.782 |
| EFM45626.1 | murG | HMPREF0580_1715 | HMPREF0580_1315 | Hypothetical protein; 1.14.99.36. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.670 |
| cobQ | EFM45207.1 | HMPREF0580_0075 | HMPREF0580_2096 | CobB/CobQ-like protein; COG: COG3442; Pfam: PF07685; InterPro: IPR011698. | FemAB family protein; Pfam: PF02388; InterPro: IPR016181. | 0.882 |
| cobQ | murE | HMPREF0580_0075 | HMPREF0580_0076 | CobB/CobQ-like protein; COG: COG3442; Pfam: PF07685; InterPro: IPR011698. | Mur ligase middle domain protein; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.999 |
| cobQ | murG | HMPREF0580_0075 | HMPREF0580_1315 | CobB/CobQ-like protein; COG: COG3442; Pfam: PF07685; InterPro: IPR011698. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.904 |
| mraY | murC | HMPREF0580_1312 | HMPREF0580_1316 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.988 |
| mraY | murD | HMPREF0580_1312 | HMPREF0580_1313 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.995 |
| mraY | murE | HMPREF0580_1312 | HMPREF0580_0076 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Mur ligase middle domain protein; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.670 |
| mraY | murF | HMPREF0580_1312 | HMPREF0580_1311 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |
| mraY | murG | HMPREF0580_1312 | HMPREF0580_1315 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.999 |
| murC | EFM45626.1 | HMPREF0580_1316 | HMPREF0580_1715 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Hypothetical protein; 1.14.99.36. | 0.552 |
| murC | mraY | HMPREF0580_1316 | HMPREF0580_1312 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.988 |
| murC | murD | HMPREF0580_1316 | HMPREF0580_1313 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.999 |
| murC | murE | HMPREF0580_1316 | HMPREF0580_0076 | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Mur ligase middle domain protein; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.729 |