| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adhC | tadA | HMPREF0580_0416 | HMPREF0580_0216 | GroES-like protein; COG: COG1062; Pfam: PF08240,PF00107; InterPro: IPR002085. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.791 |
| deoD2 | guaA | HMPREF0580_1745 | HMPREF0580_2098 | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.744 |
| deoD2 | tadA | HMPREF0580_1745 | HMPREF0580_0216 | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.881 |
| deoD2 | tilS | HMPREF0580_1745 | HMPREF0580_2292 | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.479 |
| deoD2 | upp | HMPREF0580_1745 | HMPREF0580_0215 | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.946 |
| glxK | tadA | HMPREF0580_1489 | HMPREF0580_0216 | Glycerate kinase; COG: COG1929; Pfam: PF02595; InterPro: IPR004381; Belongs to the glycerate kinase type-1 family. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.674 |
| guaA | deoD2 | HMPREF0580_2098 | HMPREF0580_1745 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | 0.744 |
| guaA | tadA | HMPREF0580_2098 | HMPREF0580_0216 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.734 |
| guaA | tilS | HMPREF0580_2098 | HMPREF0580_2292 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.951 |
| guaA | upp | HMPREF0580_2098 | HMPREF0580_0215 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.980 |
| guaA | upp2 | HMPREF0580_2098 | HMPREF0580_1525 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.556 |
| rsmI | tadA | HMPREF0580_0048 | HMPREF0580_0216 | S-adenosylmethionine-dependent methyltransferase, YraL family; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.750 |
| tadA | adhC | HMPREF0580_0216 | HMPREF0580_0416 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | GroES-like protein; COG: COG1062; Pfam: PF08240,PF00107; InterPro: IPR002085. | 0.791 |
| tadA | deoD2 | HMPREF0580_0216 | HMPREF0580_1745 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Phosphorylases family 2; COG: COG0005; Pfam: PF00896; InterPro: IPR001369. | 0.881 |
| tadA | glxK | HMPREF0580_0216 | HMPREF0580_1489 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Glycerate kinase; COG: COG1929; Pfam: PF02595; InterPro: IPR004381; Belongs to the glycerate kinase type-1 family. | 0.674 |
| tadA | guaA | HMPREF0580_0216 | HMPREF0580_2098 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.734 |
| tadA | rsmI | HMPREF0580_0216 | HMPREF0580_0048 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | S-adenosylmethionine-dependent methyltransferase, YraL family; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.750 |
| tadA | tilS | HMPREF0580_0216 | HMPREF0580_2292 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.738 |
| tadA | upp | HMPREF0580_0216 | HMPREF0580_0215 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.966 |
| tadA | upp2 | HMPREF0580_0216 | HMPREF0580_1525 | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.870 |