| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFM46560.1 | EFM46561.1 | HMPREF0580_0742 | HMPREF0580_0743 | Hypothetical protein. | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | 0.542 |
| EFM46560.1 | purE | HMPREF0580_0742 | HMPREF0580_0741 | Hypothetical protein. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.550 |
| EFM46561.1 | EFM46560.1 | HMPREF0580_0743 | HMPREF0580_0742 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Hypothetical protein. | 0.542 |
| EFM46561.1 | atpH | HMPREF0580_0743 | HMPREF0580_0760 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.456 |
| EFM46561.1 | glyA | HMPREF0580_0743 | HMPREF0580_1996 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.427 |
| EFM46561.1 | prmC | HMPREF0580_0743 | HMPREF0580_1269 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | protein-(glutamine-N5) methyltransferase, release factor-specific; COG: COG2890; Pfam: PF08241; InterPro: IPR004556; Belongs to the methyltransferase superfamily. | 0.811 |
| EFM46561.1 | purE | HMPREF0580_0743 | HMPREF0580_0741 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.437 |
| EFM46561.1 | rho | HMPREF0580_0743 | HMPREF0580_2294 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.550 |
| EFM46561.1 | rnd | HMPREF0580_0743 | HMPREF0580_1574 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Putative ribonuclease D; COG: COG0349; Pfam: PF01612,PF00570; InterPro: IPR002562. | 0.466 |
| EFM46561.1 | rpoZ | HMPREF0580_0743 | HMPREF0580_1517 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.442 |
| EFM46561.1 | sbcC | HMPREF0580_0743 | HMPREF0580_2314 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Exonuclease SbcCD, C subunit; COG: COG0419; Pfam: PF02463. | 0.507 |
| EFM46561.1 | trmD | HMPREF0580_0743 | HMPREF0580_2020 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.466 |
| atpH | EFM46561.1 | HMPREF0580_0760 | HMPREF0580_0743 | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | 0.456 |
| atpH | glyA | HMPREF0580_0760 | HMPREF0580_1996 | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.641 |
| atpH | prmC | HMPREF0580_0760 | HMPREF0580_1269 | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | protein-(glutamine-N5) methyltransferase, release factor-specific; COG: COG2890; Pfam: PF08241; InterPro: IPR004556; Belongs to the methyltransferase superfamily. | 0.895 |
| atpH | rho | HMPREF0580_0760 | HMPREF0580_2294 | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.495 |
| atpH | trmD | HMPREF0580_0760 | HMPREF0580_2020 | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.829 |
| glyA | EFM46561.1 | HMPREF0580_1996 | HMPREF0580_0743 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | 0.427 |
| glyA | atpH | HMPREF0580_1996 | HMPREF0580_0760 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.641 |
| glyA | prmC | HMPREF0580_1996 | HMPREF0580_1269 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | protein-(glutamine-N5) methyltransferase, release factor-specific; COG: COG2890; Pfam: PF08241; InterPro: IPR004556; Belongs to the methyltransferase superfamily. | 0.688 |