| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFM46928.1 | iolB | HMPREF0580_0420 | HMPREF0580_0407 | AP endonuclease, family 2; COG: COG1082; Pfam: PF01261; InterPro: IPR013022. | Myo-inositol catabolism protein IolB; COG: COG3718; Pfam: PF06845; InterPro: IPR010669. | 0.963 |
| EFM46928.1 | iolD | HMPREF0580_0420 | HMPREF0580_0406 | AP endonuclease, family 2; COG: COG1082; Pfam: PF01261; InterPro: IPR013022. | Thiamine pyrophosphate enzyme, central domain protein; COG: COG3962; Pfam: PF02776,PF00205,PF02775; InterPro: IPR011766; Belongs to the TPP enzyme family. | 0.998 |
| EFM46928.1 | kdgK | HMPREF0580_0420 | HMPREF0580_0744 | AP endonuclease, family 2; COG: COG1082; Pfam: PF01261; InterPro: IPR013022. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.642 |
| fucI | kdgK | HMPREF0580_2121 | HMPREF0580_0744 | Arabinose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.583 |
| gnd | kdgK | HMPREF0580_0745 | HMPREF0580_0744 | Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.817 |
| gnd | rpe | HMPREF0580_0745 | HMPREF0580_1510 | Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.959 |
| gnd | tkt | HMPREF0580_0745 | HMPREF0580_1391 | Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Transketolase; COG: COG0021; Pfam: PF00456,PF02779,PF02780; InterPro: IPR005478; Belongs to the transketolase family. | 0.912 |
| guaA | guaB | HMPREF0580_2098 | HMPREF0580_1176 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | kdgK | HMPREF0580_2098 | HMPREF0580_0744 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.835 |
| guaA | prs | HMPREF0580_2098 | HMPREF0580_0039 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Ribose-phosphate diphosphokinase; COG: COG0462; Pfam: PF00156; InterPro: IPR005946. | 0.887 |
| guaA | rpe | HMPREF0580_2098 | HMPREF0580_1510 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.570 |
| guaA | tkt | HMPREF0580_2098 | HMPREF0580_1391 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Transketolase; COG: COG0021; Pfam: PF00456,PF02779,PF02780; InterPro: IPR005478; Belongs to the transketolase family. | 0.535 |
| guaB | guaA | HMPREF0580_1176 | HMPREF0580_2098 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | kdgK | HMPREF0580_1176 | HMPREF0580_0744 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.727 |
| guaB | prs | HMPREF0580_1176 | HMPREF0580_0039 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Ribose-phosphate diphosphokinase; COG: COG0462; Pfam: PF00156; InterPro: IPR005946. | 0.807 |
| guaB | rpe | HMPREF0580_1176 | HMPREF0580_1510 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.535 |
| guaB | tkt | HMPREF0580_1176 | HMPREF0580_1391 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Transketolase; COG: COG0021; Pfam: PF00456,PF02779,PF02780; InterPro: IPR005478; Belongs to the transketolase family. | 0.890 |
| iolB | EFM46928.1 | HMPREF0580_0407 | HMPREF0580_0420 | Myo-inositol catabolism protein IolB; COG: COG3718; Pfam: PF06845; InterPro: IPR010669. | AP endonuclease, family 2; COG: COG1082; Pfam: PF01261; InterPro: IPR013022. | 0.963 |
| iolB | iolD | HMPREF0580_0407 | HMPREF0580_0406 | Myo-inositol catabolism protein IolB; COG: COG3718; Pfam: PF06845; InterPro: IPR010669. | Thiamine pyrophosphate enzyme, central domain protein; COG: COG3962; Pfam: PF02776,PF00205,PF02775; InterPro: IPR011766; Belongs to the TPP enzyme family. | 0.999 |
| iolB | kdgK | HMPREF0580_0407 | HMPREF0580_0744 | Myo-inositol catabolism protein IolB; COG: COG3718; Pfam: PF06845; InterPro: IPR010669. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294. | 0.792 |