| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFM46446.1 | phoR2 | HMPREF0580_0993 | HMPREF0580_0992 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518; InterPro: IPR003594. | 0.975 |
| EFM46446.1 | trkA2 | HMPREF0580_0993 | HMPREF0580_0994 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.642 |
| EFM46446.1 | trkB2 | HMPREF0580_0993 | HMPREF0580_0995 | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | Cation transport protein; COG: COG0168; Pfam: PF02386; InterPro: IPR003445. | 0.428 |
| EFM46586.1 | nadE | HMPREF0580_0768 | HMPREF0580_0564 | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | Glutamine-dependent NAD(+) synthetase domain protein; COG: COG0171; Pfam: PF02540; InterPro: IPR014729; In the C-terminal section; belongs to the NAD synthetase family. | 0.949 |
| EFM46586.1 | rsmB | HMPREF0580_0768 | HMPREF0580_1511 | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.474 |
| EFM46586.1 | trkA2 | HMPREF0580_0768 | HMPREF0580_0994 | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.564 |
| EFM46586.1 | trkB | HMPREF0580_0768 | HMPREF0580_0117 | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | Cation transport protein; COG: COG0168; Pfam: PF02386; InterPro: IPR003445. | 0.690 |
| EFM46586.1 | trkB2 | HMPREF0580_0768 | HMPREF0580_0995 | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | Cation transport protein; COG: COG0168; Pfam: PF02386; InterPro: IPR003445. | 0.690 |
| hemD | nadE | HMPREF0580_0361 | HMPREF0580_0564 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamine-dependent NAD(+) synthetase domain protein; COG: COG0171; Pfam: PF02540; InterPro: IPR014729; In the C-terminal section; belongs to the NAD synthetase family. | 0.633 |
| hemD | trkA2 | HMPREF0580_0361 | HMPREF0580_0994 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.544 |
| nadE | EFM46586.1 | HMPREF0580_0564 | HMPREF0580_0768 | Glutamine-dependent NAD(+) synthetase domain protein; COG: COG0171; Pfam: PF02540; InterPro: IPR014729; In the C-terminal section; belongs to the NAD synthetase family. | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | 0.949 |
| nadE | hemD | HMPREF0580_0564 | HMPREF0580_0361 | Glutamine-dependent NAD(+) synthetase domain protein; COG: COG0171; Pfam: PF02540; InterPro: IPR014729; In the C-terminal section; belongs to the NAD synthetase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.633 |
| nadE | trkA2 | HMPREF0580_0564 | HMPREF0580_0994 | Glutamine-dependent NAD(+) synthetase domain protein; COG: COG0171; Pfam: PF02540; InterPro: IPR014729; In the C-terminal section; belongs to the NAD synthetase family. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.698 |
| phoR2 | EFM46446.1 | HMPREF0580_0992 | HMPREF0580_0993 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518; InterPro: IPR003594. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.975 |
| phoR2 | trkA2 | HMPREF0580_0992 | HMPREF0580_0994 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518; InterPro: IPR003594. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.509 |
| rsmB | EFM46586.1 | HMPREF0580_1511 | HMPREF0580_0768 | Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; COG: COG0674; Pfam: PF01855,PF01558,PF00037; InterPro: IPR002869. | 0.474 |
| rsmB | trkA2 | HMPREF0580_1511 | HMPREF0580_0994 | Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.666 |
| rsmB | trkB | HMPREF0580_1511 | HMPREF0580_0117 | Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Cation transport protein; COG: COG0168; Pfam: PF02386; InterPro: IPR003445. | 0.496 |
| rsmB | trkB2 | HMPREF0580_1511 | HMPREF0580_0995 | Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Cation transport protein; COG: COG0168; Pfam: PF02386; InterPro: IPR003445. | 0.496 |
| trkA2 | EFM46446.1 | HMPREF0580_0994 | HMPREF0580_0993 | TrkA N-terminal domain protein; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.642 |