| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alaS | argS | HMPREF0580_1536 | HMPREF0580_2300 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | 0.564 |
| alaS | glyS | HMPREF0580_1536 | HMPREF0580_1069 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.781 |
| alaS | ileS | HMPREF0580_1536 | HMPREF0580_1195 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | isoleucine--tRNA ligase; COG: COG0060; Pfam: PF00133,PF08264; InterPro: IPR002301. | 0.806 |
| alaS | leuS | HMPREF0580_1536 | HMPREF0580_0846 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | leucine--tRNA ligase; COG: COG0495; Pfam: PF09334,PF00133,PF08264; InterPro: IPR002302; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.860 |
| alaS | pheT | HMPREF0580_1536 | HMPREF0580_1802 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.983 |
| alaS | serS | HMPREF0580_1536 | HMPREF0580_0238 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.594 |
| alaS | tyrS | HMPREF0580_1536 | HMPREF0580_1791 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.650 |
| argS | alaS | HMPREF0580_2300 | HMPREF0580_1536 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | 0.564 |
| argS | glyS | HMPREF0580_2300 | HMPREF0580_1069 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.740 |
| argS | ileS | HMPREF0580_2300 | HMPREF0580_1195 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | isoleucine--tRNA ligase; COG: COG0060; Pfam: PF00133,PF08264; InterPro: IPR002301. | 0.988 |
| argS | leuS | HMPREF0580_2300 | HMPREF0580_0846 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | leucine--tRNA ligase; COG: COG0495; Pfam: PF09334,PF00133,PF08264; InterPro: IPR002302; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.989 |
| argS | pheT | HMPREF0580_2300 | HMPREF0580_1802 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.926 |
| argS | polA | HMPREF0580_2300 | HMPREF0580_1480 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | DNA-directed DNA polymerase; COG: COG0749; Pfam: PF02739,PF01367,PF00476; InterPro: IPR002298. | 0.670 |
| argS | serS | HMPREF0580_2300 | HMPREF0580_0238 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.727 |
| argS | tyrS | HMPREF0580_2300 | HMPREF0580_1791 | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.872 |
| cdd | glyS | HMPREF0580_1385 | HMPREF0580_1069 | Putative cytidine deaminase; COG: COG0295; Pfam: PF00383; InterPro: IPR002125. | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.725 |
| cdd | pheT | HMPREF0580_1385 | HMPREF0580_1802 | Putative cytidine deaminase; COG: COG0295; Pfam: PF00383; InterPro: IPR002125. | phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.441 |
| glyS | alaS | HMPREF0580_1069 | HMPREF0580_1536 | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | 0.781 |
| glyS | argS | HMPREF0580_1069 | HMPREF0580_2300 | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278. | 0.740 |
| glyS | cdd | HMPREF0580_1069 | HMPREF0580_1385 | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. | Putative cytidine deaminase; COG: COG0295; Pfam: PF00383; InterPro: IPR002125. | 0.725 |