STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acoDDihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes). (467 aa)    
Predicted Functional Partners:
acoC
acoC; dihydrolipoamide acetyltransferase.
 0.998
sucB
Dihydrolipoamide succinyltransferase, component of 2-oxoglutarate dehydrogenase complex (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.990
aceF
Dihydrolipoamide S-acetyltransferase, E2 component of the pyruvate dehydrogenase complex.
 0.988
acoB
Acetoin:2,6-dichlorophenolindophenol oxidoreductase beta subunit.
 
 0.985
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
  
 0.977
acoA
Acetoin:2,6-dichlorophenolindophenol oxidoreductase alpha subunit.
 
 
 0.975
sucA
2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex (E1).
 
 0.974
aceE
Pyruvate decarboxylase, E1 component of the pyruvate dehydrogenase complex; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.939
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.928
pdhD
Putative pyridine nucleotide-disulfide oxidoreductase, class I.
  
  
 
0.927
Your Current Organism:
Acinetobacter pittii
NCBI taxonomy Id: 871585
Other names: A. pittii PHEA-2, Acinetobacter calcoaceticus PHEA-2, Acinetobacter calcoaceticus str. PHEA-2, Acinetobacter calcoaceticus strain PHEA-2, Acinetobacter pittii PHEA-2
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