clpC protein (Streptococcus criceti) - STRING interaction network

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clpC

ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (813 aa)

Predicted Functional Partners:

clpP

0.972

ctsR

0.939

dnaK

0.874

clpX

0.864

mecA

0.761

dnaJ

0.746

grpE

0.673

groES

0.670

groL

0.655

guaB

0.480

Your Current Organism:

Streptococcus criceti

NCBI taxonomy Id: 873449
Other names: S. criceti HS-6, Streptococcus criceti HS-6, Streptococcus criceti str. HS-6, Streptococcus criceti strain HS-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
clpC	clpP	STRCR_0215	STRCR_2338	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.972
clpC	clpX	STRCR_0215	STRCR_1390	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.864
clpC	ctsR	STRCR_0215	STRCR_0216	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Transcriptional regulator CtsR; Belongs to the CtsR family.	0.939
clpC	dnaJ	STRCR_0215	STRCR_0591	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]	0.746
clpC	dnaK	STRCR_0215	STRCR_0590	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.874
clpC	groES	STRCR_0215	STRCR_0167	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.670
clpC	groL	STRCR_0215	STRCR_0166	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.655
clpC	grpE	STRCR_0215	STRCR_0589	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...]	0.673
clpC	guaB	STRCR_0215	STRCR_0387	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.480
clpC	mecA	STRCR_0215	STRCR_0631	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Adapter protein MecA family protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.761
clpP	clpC	STRCR_2338	STRCR_0215	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease, ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	0.972
clpP	clpX	STRCR_2338	STRCR_1390	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.999
clpP	ctsR	STRCR_2338	STRCR_0216	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Transcriptional regulator CtsR; Belongs to the CtsR family.	0.728
clpP	dnaJ	STRCR_2338	STRCR_0591	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]	0.724
clpP	dnaK	STRCR_2338	STRCR_0590	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.806
clpP	groES	STRCR_2338	STRCR_0167	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.890
clpP	groL	STRCR_2338	STRCR_0166	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.887
clpP	grpE	STRCR_2338	STRCR_0589	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...]	0.835
clpP	guaB	STRCR_2338	STRCR_0387	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.506
clpP	mecA	STRCR_2338	STRCR_0631	ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Adapter protein MecA family protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.663