| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHI73893.1 | EHI74676.1 | STRCR_0904 | STRCR_0905 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.509 |
| EHI73893.1 | clpP | STRCR_0904 | STRCR_2338 | Hypothetical protein; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.876 |
| EHI73893.1 | ctsR | STRCR_0904 | STRCR_0216 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Transcriptional regulator CtsR; Belongs to the CtsR family. | 0.526 |
| EHI73893.1 | dnaJ | STRCR_0904 | STRCR_0591 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | 0.705 |
| EHI73893.1 | dnaK | STRCR_0904 | STRCR_0590 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Putative chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.903 |
| EHI73893.1 | groES | STRCR_0904 | STRCR_0167 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.497 |
| EHI73893.1 | groL | STRCR_0904 | STRCR_0166 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Putative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.540 |
| EHI73893.1 | grpE | STRCR_0904 | STRCR_0589 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Putative protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...] | 0.666 |
| EHI73893.1 | guaB | STRCR_0904 | STRCR_0387 | Hypothetical protein; Belongs to the ClpA/ClpB family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.432 |
| EHI73893.1 | mecA | STRCR_0904 | STRCR_0631 | Hypothetical protein; Belongs to the ClpA/ClpB family. | Adapter protein MecA family protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.746 |
| EHI74676.1 | EHI73893.1 | STRCR_0905 | STRCR_0904 | Hypothetical protein. | Hypothetical protein; Belongs to the ClpA/ClpB family. | 0.509 |
| EHI74676.1 | dnaJ | STRCR_0905 | STRCR_0591 | Hypothetical protein. | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | 0.712 |
| clpP | EHI73893.1 | STRCR_2338 | STRCR_0904 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein; Belongs to the ClpA/ClpB family. | 0.876 |
| clpP | dnaJ | STRCR_2338 | STRCR_0591 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | 0.626 |
| clpP | dnaK | STRCR_2338 | STRCR_0590 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Putative chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.716 |
| clpP | groES | STRCR_2338 | STRCR_0167 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.839 |
| clpP | groL | STRCR_2338 | STRCR_0166 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Putative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.728 |
| clpP | grpE | STRCR_2338 | STRCR_0589 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Putative protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...] | 0.694 |
| clpP | guaB | STRCR_2338 | STRCR_0387 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.553 |
| ctsR | EHI73893.1 | STRCR_0216 | STRCR_0904 | Transcriptional regulator CtsR; Belongs to the CtsR family. | Hypothetical protein; Belongs to the ClpA/ClpB family. | 0.526 |
STRING v12.5 is now available!
