Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EHI74248.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (427 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase.
 0.999
EHI73887.1
hydroxymethylglutaryl-CoA synthase.
 
 0.998
mvaD
Pyrophosphomevalonate decarboxylase.
 
 
 0.951
EHI75214.1
Phosphomevalonate kinase.
 
 0.941
fni
Putative Isopentenyl-pyrophosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.895
EHI73985.1
Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
 
 0.780
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.576
EHI73936.1
Homoserine dehydrogenase family protein.
     
 0.559
thrB
Putative homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
       0.547
rarD
Protein RarD.
       0.547
Your Current Organism:
Streptococcus criceti
NCBI taxonomy Id: 873449
Other names: S. criceti HS-6, Streptococcus criceti HS-6, Streptococcus criceti str. HS-6, Streptococcus criceti strain HS-6
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