| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHI74067.1 | EHI74687.1 | STRCR_0450 | STRCR_1121 | Phosphoribosylformylglycinamidine synthase. | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | 0.817 |
| EHI74067.1 | fhs | STRCR_0450 | STRCR_1319 | Phosphoribosylformylglycinamidine synthase. | Putative Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.885 |
| EHI74067.1 | folD | STRCR_0450 | STRCR_2179 | Phosphoribosylformylglycinamidine synthase. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.929 |
| EHI74067.1 | glyA | STRCR_0450 | STRCR_1613 | Phosphoribosylformylglycinamidine synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
| EHI74067.1 | purH | STRCR_0450 | STRCR_0457 | Phosphoribosylformylglycinamidine synthase. | Putative bifunctional purine biosynthesis protein PurH. | 0.999 |
| EHI74067.1 | purN | STRCR_0450 | STRCR_0454 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| EHI74687.1 | EHI74067.1 | STRCR_1121 | STRCR_0450 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Phosphoribosylformylglycinamidine synthase. | 0.817 |
| EHI74687.1 | EHI75284.1 | STRCR_1121 | STRCR_1990 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.976 |
| EHI74687.1 | fhs | STRCR_1121 | STRCR_1319 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Putative Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.774 |
| EHI74687.1 | folD | STRCR_1121 | STRCR_2179 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
| EHI74687.1 | glyA | STRCR_1121 | STRCR_1613 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
| EHI74687.1 | thyA | STRCR_1121 | STRCR_1387 | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.934 |
| EHI75284.1 | EHI74687.1 | STRCR_1990 | STRCR_1121 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Putative TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase. | 0.976 |
| EHI75284.1 | fhs | STRCR_1990 | STRCR_1319 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Putative Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.983 |
| EHI75284.1 | folD | STRCR_1990 | STRCR_2179 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.978 |
| EHI75284.1 | glyA | STRCR_1990 | STRCR_1613 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
| EHI75284.1 | purH | STRCR_1990 | STRCR_0457 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Putative bifunctional purine biosynthesis protein PurH. | 0.945 |
| EHI75284.1 | purN | STRCR_1990 | STRCR_0454 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.942 |
| EHI75284.1 | serB | STRCR_1990 | STRCR_1799 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Phosphoserine phosphatase SerB. | 0.904 |
| EHI75284.1 | thyA | STRCR_1990 | STRCR_1387 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
