| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHI73801.1 | awd | STRCR_0183 | STRCR_1200 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Nucleoside pyrophosphate kinase. | 0.962 |
| EHI73801.1 | rdgB | STRCR_0183 | STRCR_2121 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.956 |
| EHI74535.1 | murI | STRCR_2120 | STRCR_2122 | Phosphoesterase family protein. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.846 |
| EHI74535.1 | rdgB | STRCR_2120 | STRCR_2121 | Phosphoesterase family protein. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
| EHI75414.1 | guaA | STRCR_1916 | STRCR_1553 | Glutamine amidotransferase, class I. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.914 |
| EHI75414.1 | guaB | STRCR_1916 | STRCR_0387 | Glutamine amidotransferase, class I. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.986 |
| EHI75414.1 | guaC | STRCR_1916 | STRCR_1643 | Glutamine amidotransferase, class I. | Putative GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.945 |
| EHI75414.1 | purA | STRCR_1916 | STRCR_0145 | Glutamine amidotransferase, class I. | Putative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.434 |
| EHI75414.1 | rdgB | STRCR_1916 | STRCR_2121 | Glutamine amidotransferase, class I. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.915 |
| awd | EHI73801.1 | STRCR_1200 | STRCR_0183 | Nucleoside pyrophosphate kinase. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.962 |
| awd | guaA | STRCR_1200 | STRCR_1553 | Nucleoside pyrophosphate kinase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.659 |
| awd | guaB | STRCR_1200 | STRCR_0387 | Nucleoside pyrophosphate kinase. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.651 |
| awd | rdgB | STRCR_1200 | STRCR_2121 | Nucleoside pyrophosphate kinase. | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.963 |
| guaA | EHI75414.1 | STRCR_1553 | STRCR_1916 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glutamine amidotransferase, class I. | 0.914 |
| guaA | awd | STRCR_1553 | STRCR_1200 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside pyrophosphate kinase. | 0.659 |
| guaA | guaB | STRCR_1553 | STRCR_0387 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | guaC | STRCR_1553 | STRCR_1643 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.998 |
| guaA | murI | STRCR_1553 | STRCR_2122 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.684 |
| guaA | purA | STRCR_1553 | STRCR_0145 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.891 |
| guaA | purH | STRCR_1553 | STRCR_0457 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative bifunctional purine biosynthesis protein PurH. | 0.900 |
