Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pheSphenylalanine--tRNA ligase, alpha subunit; COG: COG0016; Pfam: PF02912,PF01409; InterPro: IPR004529; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (415 aa)    
Predicted Functional Partners:
pheT
phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
 
 0.999
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.970
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
   
  
 0.748
serS
serine--tRNA ligase; COG: COG0172; Pfam: PF02403,PF00587; InterPro: IPR002317.
  
 
 0.743
murB
UDP-N-acetylmuramate dehydrogenase; Cell wall formation.
     
 0.714
lipB
Metallo-beta-lactamase domain protein; COG: COG1235; Pfam: PF00753; InterPro: IPR001279.
       0.691
EFU30019.1
Hypothetical protein.
       0.691
rplE
Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
  
  
 0.636
rpsG
Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
   
  
 0.630
tyrS
tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
  
  
 0.613
Your Current Organism:
Prevotella buccae
NCBI taxonomy Id: 873513
Other names: P. buccae ATCC 33574, Prevotella buccae ATCC 33574, Prevotella buccae CIP 105106, Prevotella buccae str. ATCC 33574, Prevotella buccae strain ATCC 33574
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