STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCsuccinyl-CoA synthetase (beta chain) SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (391 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA synthetase (alpha chain) SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
kgd
Alpha-ketoglutarate decarboxylase Kgd.
 
 
 0.997
sdhB
Succinate dehydrogenase (iron-sulfur protein subunit) SdhB.
 
 0.986
sucB
Pyruvate dehydrogenase (E2 component) SucB.
  
 0.982
sdhB_1
Succinate dehydrogenase (iron-sulfur subunit) SdhB_1.
 
 0.980
sdhC
Succinate dehydrogenase (cytochrome B-556 subunit) SdhC.
  
 
 0.980
sdhA-3
Succinate dehydrogenase (flavoprotein subunit) SdhA.
 
 0.979
porA
Pyruvate:ferredoxin oxidoreductase PorA alpha subunit.
  
 
 0.978
sdhD
Succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD.
  
 
 0.977
sdhA
Succinate dehydrogenase (iron-sulfur subunit) SdhA_1.
 
 0.974
Your Current Organism:
Mycolicibacter sinensis
NCBI taxonomy Id: 875328
Other names: M. sinensis, Mycobacterium sinense, Mycobacterium sinov, Mycobacterium sp. 506, Mycobacterium sp. JDM601, strain JDM601
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.