node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR27320.1 | EAR29093.1 | PTD2_14812 | PTD2_08614 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | 0.946 |
EAR27320.1 | FolA | PTD2_14812 | PTD2_08534 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.910 |
EAR27320.1 | folD | PTD2_14812 | PTD2_15497 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
EAR27320.1 | gcvT | PTD2_14812 | PTD2_14817 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.976 |
EAR27320.1 | glyA | PTD2_14812 | PTD2_09219 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
EAR27320.1 | purN | PTD2_14812 | PTD2_22657 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
EAR27320.1 | purT | PTD2_14812 | PTD2_09768 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.906 |
EAR27320.1 | purU | PTD2_14812 | PTD2_08559 | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.915 |
EAR29093.1 | EAR27320.1 | PTD2_08614 | PTD2_14812 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | 0.946 |
EAR29093.1 | FolA | PTD2_08614 | PTD2_08534 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.917 |
EAR29093.1 | folD | PTD2_08614 | PTD2_15497 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.445 |
EAR29093.1 | gcvT | PTD2_08614 | PTD2_14817 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.946 |
EAR29093.1 | glyA | PTD2_08614 | PTD2_09219 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.933 |
EAR29093.1 | purN | PTD2_08614 | PTD2_22657 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
EAR29093.1 | purT | PTD2_08614 | PTD2_09768 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
EAR29093.1 | purU | PTD2_08614 | PTD2_08559 | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.913 |
FolA | EAR27320.1 | PTD2_08534 | PTD2_14812 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Putative orphan protein; COG0404 Glycine cleavage system T protein (aminomethyltransferase). | 0.910 |
FolA | EAR29093.1 | PTD2_08534 | PTD2_08614 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | 0.917 |
FolA | gcvT | PTD2_08534 | PTD2_14817 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.910 |
FolA | glyA | PTD2_08534 | PTD2_09219 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |