STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ08319.1SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: Isopropylmalate/citramalate/homocitrate synthase; KEGG: mth:MTH1481 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)    
Predicted Functional Partners:
ilvD
PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: mmg:MTBMA_c00370 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.987
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.986
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.981
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.964
ADZ09617.1
Propanoyl-CoA C-acyltransferase; KEGG: mmg:MTBMA_c11890 acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal.
  
 
 0.948
ADZ08346.1
KEGG: mfv:Mfer_0053 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT.
  
 
 0.929
ADZ08818.1
TIGRFAM: Acetate-CoA ligase; KEGG: mmg:MTBMA_c01900 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase.
  
 
 0.927
ADZ09939.1
acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; manually curated; KEGG: mth:MTH217 acetyl-CoA synthetase; TIGRFAM: Acetate-CoA ligase.
  
 
 0.927
ADZ10118.1
TIGRFAM: Acetate-CoA ligase; KEGG: mfv:Mfer_0074 acetyl-coenzyme a synthetase; PFAM: AMP-dependent synthetase/ligase.
  
 
 0.927
ADZ10668.1
Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase.
  
 
 0.927
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.