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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ08348.1UPF0285 protein; KEGG: mmg:MTBMA_c00280 putative carbohydrate kinase of the FGGY family; TIGRFAM: Uncharacterised protein family UPF0285, methanogenesis; HAMAP: Uncharacterised protein family UPF0285, methanogenesis; Belongs to the UPF0285 family. (333 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.839
ADZ08346.1
KEGG: mfv:Mfer_0053 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT.
 
     0.724
ADZ08293.1
PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; KEGG: mmg:MTBMA_c01080 HypE-related protein.
  
     0.708
mtrA
Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
  
     0.674
ADZ10412.1
PFAM: Uncharacterised conserved protein UCP006577; KEGG: mru:mru_1621 hypothetical protein.
  
     0.671
ADZ10725.1
4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S binding domain; KEGG: mru:mru_0341 tungsten formylmethanofuran dehydrogenase subunit G FwdG.
  
     0.671
ADZ08600.1
Methanogenesis marker protein 10; KEGG: mmg:MTBMA_c15530 Fe-S oxidoreductase; TIGRFAM: Putative methanogenesis marker protein 10; PFAM: Domain of unknown function DUF512; Radical SAM.
  
     0.666
mtrC
Tetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
     0.662
mtrE
Tetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
     0.659
mtrG
Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
     0.646
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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