STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ08436.1KEGG: mth:MTH1400 hypothetical protein. (317 aa)    
Predicted Functional Partners:
ADZ08435.1
KEGG: mth:MTH1399 hypothetical protein.
       0.863
ADZ08437.1
Transcriptional regulator, AsnC family; KEGG: mst:Msp_1556 transcriptional regulator; PFAM: Transcription regulator AsnC-type, C-terminal; SMART: Transcription regulator AsnC-type.
       0.468
ADZ08434.1
PFAM: Domain of unknown function DUF35, OB-fold, C-terminal; KEGG: mmg:MTBMA_c17840 nucleic acid-binding protein.
       0.435
cbiX
Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
       0.419
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.416
ADZ08438.1
MgtE intracellular region; KEGG: mst:Msp_1555 hypothetical protein; PFAM: Magnesium transporter, MgtE intracellular domain; Cystathionine beta-synthase, core; SMART: Magnesium transporter, MgtE intracellular domain; Cystathionine beta-synthase, core.
       0.411
ADZ08439.1
PFAM: Natural resistance-associated macrophage protein; KEGG: mst:Msp_1554 Mn2+/Fe2+ transporter.
       0.406
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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