Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ADZ08453.1UPF0215 protein; Manually curated; HAMAP: Protein of unknown function DUF99; KEGG: mmg:MTBMA_c17020 hypothetical protein; PFAM: Protein of unknown function DUF99; Belongs to the UPF0215 family. (202 aa)    
Predicted Functional Partners:
csl4
RNA-binding domain, S1; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
 
     0.922
ADZ08452.1
PFAM: DNA-directed RNA polymerase, dimerisation; KEGG: mth:MTH1317 DNA-dependent RNA polymerase, subunit L.
 
     0.883
ADZ08454.1
PFAM: NUDIX hydrolase domain; KEGG: mst:Msp_1534 putative ADP-ribose pyrophosphatase.
       0.816
ADZ08450.1
Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
       0.628
ADZ08455.1
Transcription termination factor Tfs; TIGRFAM: DNA-directed RNA polymerase, subunit M, archaeal; PFAM: Zinc finger, TFIIS-type; DNA-directed RNA polymerase, M/15kDa subunit; KEGG: mst:Msp_1533 RpoM1; SMART: Zinc finger, TFIIS-type; DNA-directed RNA polymerase, M/15kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
       0.606
ADZ08271.1
PFAM: Divalent ion tolerance protein, CutA1; KEGG: mth:MTH1509 divalent cation tolerance protein.
       0.541
hpt
Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
       0.513
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
       0.510
rps27ae
KEGG: mst:Msp_0620 30S ribosomal protein S27ae; HAMAP: Ribosomal protein S27ae; PFAM: Ribosomal protein S27a; Belongs to the eukaryotic ribosomal protein eS31 family.
 
     0.479
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
       0.478
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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