Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ08594.1KEGG: mru:mru_1950 TraB family protein; TIGRFAM: Pheromone shutdown, TraB; PFAM: Pheromone shutdown-related, TraB. (384 aa)    
Predicted Functional Partners:
ADZ08592.1
PFAM: Protein of unknown function DUF1922; KEGG: mth:MTH1184 hypothetical protein.
       0.802
comB
PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulpholactate phosphatase; HAMAP: 2-phosphosulpholactate phosphatase ComB; KEGG: mfv:Mfer_1236 2-phosphosulfolactate phosphatase.
       0.798
ADZ08593.1
PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cbi:CLJ_B1067 CDP-alcohol phosphatidyltransferase family protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.676
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
    
 
 0.674
ADZ09712.1
Heat shock protein DnaJ domain protein; KEGG: pfh:PFHG_00645 hypothetical protein similar to chaperone protein J; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal.
    
 
 0.674
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
   
   0.660
ADZ10324.1
Long-chain-fatty-acid--CoA ligase; KEGG: mth:MTH657 AMP-binding domain protein; PFAM: AMP-dependent synthetase/ligase.
   
   0.656
ADZ08523.1
4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S binding domain; KEGG: mmg:MTBMA_c16280 energy-converting hydrogenase B, subunit L.
    
   0.651
ADZ10331.1
TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein; KEGG: mmh:Mmah_0726 succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: Ferredoxin.
    
   0.651
ADZ10731.1
NADH dehydrogenase (quinone); PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S binding domain; KEGG: mth:MTH1549 NADP-reducing hydrogenase, subunit C; SMART: NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding.
    
   0.651
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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