STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ08710.1PFAM: Protein of unknown function DUF112, transmembrane; KEGG: msi:Msm_0599 hypothetical protein. (449 aa)    
Predicted Functional Partners:
ADZ08445.1
PFAM: RNA polymerase II, Rpb4; KEGG: mth:MTH1324 hypothetical protein.
  
     0.594
ADZ10339.1
PFAM: Phosphoesterase, DHHA1; Phosphoesterase, RecJ-like; KEGG: mst:Msp_1189 hypothetical protein.
 
     0.591
rnp4
Ribonuclease P protein component 4; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  
     0.583
ADZ08357.1
PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: msi:Msm_1193 single-stranded DNA-specific exonuclease.
 
     0.572
ef1b
Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
 
     0.567
ADZ08360.1
Helicase domain protein; KEGG: mth:MTH1415 Hef nuclease; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; ERCC4 domain; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; ERCC4 domain; Helix-hairpin-helix DNA-binding motif, class 1.
  
     0.536
endA
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
     0.524
cca
CCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
     0.522
spt4
DNA-dependent RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
 
     0.519
ADZ08444.1
PFAM: Protein of unknown function DUF655; KEGG: mth:MTH1325 hypothetical protein.
  
     0.518
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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