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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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cdhECO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (462 aa)    
Predicted Functional Partners:
cdhA
Acetyl-CoA decarbonylase/synthase complex subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
 
 0.999
cdhC
CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.
 
 0.999
cdhD
CO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.
 
 0.999
cdhB
Acetyl-CoA decarbonylase/synthase complex subunit epsilon; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family.
 
 
 0.996
ADZ08717.1
PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: mmp:MMP0982 hypothetical protein.
 
  
 0.995
ADZ08720.1
PFAM: 4Fe-4S binding domain; KEGG: mmz:MmarC7_0221 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein.
  
    0.961
ftr
Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
     
 0.950
ADZ09617.1
Propanoyl-CoA C-acyltransferase; KEGG: mmg:MTBMA_c11890 acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal.
     
 0.950
ADZ09939.1
acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; manually curated; KEGG: mth:MTH217 acetyl-CoA synthetase; TIGRFAM: Acetate-CoA ligase.
   
 
 0.948
ADZ10668.1
Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase.
   
 
 0.948
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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