Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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ADZ08784.1Phosphodiesterase, MJ0936 family; KEGG: mth:MTH1774 hypothetical protein; TIGRFAM: Phosphodiesterase MJ0936; PFAM: Metallo-dependent phosphatase. (174 aa)    
Predicted Functional Partners:
rlmE
Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
  
    0.923
ADZ08781.1
KEGG: mfv:Mfer_0045 mcm family protein; PFAM: DNA-dependent ATPase MCM; SMART: DNA-dependent ATPase MCM; Hedgehog/intein hint, N-terminal; Hedgehog/intein hint domain, C-terminal; Belongs to the MCM family.
       0.746
ADZ09250.1
Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.737
ADZ10340.1
Regulatory protein Crp; SMART: HTH transcriptional regulator, Crp; KEGG: mst:Msp_1188 transcriptional regulator.
 
     0.601
ADZ08355.1
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.567
ADZ10391.1
PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: mst:Msp_1258 ribokinase.
  
  
 0.553
ADZ10548.1
KEGG: mth:MTH886 H/ACA RNA-protein complex component Gar1.
       0.541
ADZ08988.1
PFAM: GTP-binding protein, HSR1-related; KEGG: mmg:MTBMA_c04750 GTP-binding protein.
   
 
 0.501
atpF
V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
  
 0.449
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.422
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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