| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADZ08869.1 | ADZ08878.1 | Metbo_0618 | Metbo_0627 | NADPH-dependent F420 reductase; KEGG: mth:MTH248 hypothetical protein; TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent. | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | 0.727 |
| ADZ08877.1 | ADZ08878.1 | Metbo_0626 | Metbo_0627 | KEGG: mth:MTH561 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00267; PFAM: Domain of unknown function DUF125, transmembrane. | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | 0.814 |
| ADZ08877.1 | ADZ08880.1 | Metbo_0626 | Metbo_0629 | KEGG: mth:MTH561 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00267; PFAM: Domain of unknown function DUF125, transmembrane. | KEGG: mth:MTH564 hypothetical protein. | 0.430 |
| ADZ08877.1 | sucD | Metbo_0626 | Metbo_0628 | KEGG: mth:MTH561 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00267; PFAM: Domain of unknown function DUF125, transmembrane. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.560 |
| ADZ08878.1 | ADZ08869.1 | Metbo_0627 | Metbo_0618 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | NADPH-dependent F420 reductase; KEGG: mth:MTH248 hypothetical protein; TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent. | 0.727 |
| ADZ08878.1 | ADZ08877.1 | Metbo_0627 | Metbo_0626 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | KEGG: mth:MTH561 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00267; PFAM: Domain of unknown function DUF125, transmembrane. | 0.814 |
| ADZ08878.1 | ADZ08880.1 | Metbo_0627 | Metbo_0629 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | KEGG: mth:MTH564 hypothetical protein. | 0.775 |
| ADZ08878.1 | ADZ09073.1 | Metbo_0627 | Metbo_0822 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | Dimethylallyltranstransferase; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. | 0.879 |
| ADZ08878.1 | ADZ09617.1 | Metbo_0627 | Metbo_1377 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | Propanoyl-CoA C-acyltransferase; KEGG: mmg:MTBMA_c11890 acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal. | 0.784 |
| ADZ08878.1 | ADZ09618.1 | Metbo_0627 | Metbo_1378 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | UPF0219 protein; TIGRFAM: Putative condensing enzyme FabH-related; HAMAP: Putative condensing enzyme FabH-related; KEGG: mmg:MTBMA_c11880 3-hydroxy-3-methylglutaryl-CoA-synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; Hydroxymethylglutaryl-coenzyme A synthase, N-terminal; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.999 |
| ADZ08878.1 | ADZ10220.1 | Metbo_0627 | Metbo_2001 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | PFAM: UbiA prenyltransferase; KEGG: mem:Memar_2408 UbiA prenyltransferase. | 0.738 |
| ADZ08878.1 | ADZ10221.1 | Metbo_0627 | Metbo_2002 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | PFAM: UbiA prenyltransferase; KEGG: mem:Memar_2408 UbiA prenyltransferase. | 0.738 |
| ADZ08878.1 | mvk | Metbo_0627 | Metbo_0818 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.987 |
| ADZ08878.1 | sucD | Metbo_0627 | Metbo_0628 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.824 |
| ADZ08880.1 | ADZ08877.1 | Metbo_0629 | Metbo_0626 | KEGG: mth:MTH564 hypothetical protein. | KEGG: mth:MTH561 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00267; PFAM: Domain of unknown function DUF125, transmembrane. | 0.430 |
| ADZ08880.1 | ADZ08878.1 | Metbo_0629 | Metbo_0627 | KEGG: mth:MTH564 hypothetical protein. | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | 0.775 |
| ADZ08880.1 | sucD | Metbo_0629 | Metbo_0628 | KEGG: mth:MTH564 hypothetical protein. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.853 |
| ADZ09073.1 | ADZ08878.1 | Metbo_0822 | Metbo_0627 | Dimethylallyltranstransferase; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. | 0.879 |
| ADZ09073.1 | ADZ09617.1 | Metbo_0822 | Metbo_1377 | Dimethylallyltranstransferase; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. | Propanoyl-CoA C-acyltransferase; KEGG: mmg:MTBMA_c11890 acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal. | 0.459 |
| ADZ09073.1 | ADZ09618.1 | Metbo_0822 | Metbo_1378 | Dimethylallyltranstransferase; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. | UPF0219 protein; TIGRFAM: Putative condensing enzyme FabH-related; HAMAP: Putative condensing enzyme FabH-related; KEGG: mmg:MTBMA_c11880 3-hydroxy-3-methylglutaryl-CoA-synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; Hydroxymethylglutaryl-coenzyme A synthase, N-terminal; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.758 |
