STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ08943.1PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. (340 aa)    
Predicted Functional Partners:
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.763
ADZ10586.1
KH domain protein; KEGG: mth:MTH1006 putative RNA-processing protein; TIGRFAM: KH domain protein, archaea; SMART: K Homology.
 
    0.703
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
 
     0.570
ADZ10146.1
Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: mst:Msp_0372 histone acetyltransferase; PFAM: Radical SAM; GCN5-related N-acetyltransferase (GNAT) domain.
 
  
 0.567
ADZ08558.1
KEGG: mru:mru_1987 pre-mRNA splicing ribonucleoprotein PRP31; PFAM: Pre-mRNA processing ribonucleoprotein, snoRNA-binding domain; NOSIC; SMART: NOSIC.
  
  
 0.552
trm1
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
  
 0.546
eif2g
Translation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
 
    0.542
eif1a
Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
 
     0.534
nac
Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.533
ADZ08945.1
DNA adenine methylase; Manually curated; TIGRFAM: D12 class N6 adenine-specific DNA methyltransferase; KEGG: tit:Thit_0485 DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase.
       0.529
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.