Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ08943.1PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. (340 aa)    
Predicted Functional Partners:
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.865
ADZ10146.1
Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: mst:Msp_0372 histone acetyltransferase; PFAM: Radical SAM; GCN5-related N-acetyltransferase (GNAT) domain.
 
  
 0.727
ADZ10586.1
KH domain protein; KEGG: mth:MTH1006 putative RNA-processing protein; TIGRFAM: KH domain protein, archaea; SMART: K Homology.
 
    0.707
taw1
Wyosine base formation domain-containing protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
 
  
 0.647
ADZ08843.1
Manually curated; PFAM: ABC transporter-like; RNase L inhibitor RLI, possible metal-binding domain; 4Fe-4S binding domain; KEGG: mth:MTH1695 putative ATPase RIL; SMART: ATPase, AAA+ type, core.
 
    0.621
hel308
DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
 
     0.619
ef1b
Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
 
   
 0.597
ADZ08744.1
Protein of unknown function UPF0021; KEGG: mru:mru_0562 PP-loop family protein; TIGRFAM: tRNA 2-thiolation protein; PFAM: tRNA(Ile)-lysidine/2-thiocytidine synthase.
  
  
 0.595
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
 
    0.576
ADZ08932.1
SMART: Nucleotide binding protein, PINc; KEGG: mru:mru_1781 hypothetical protein.
 
    0.575
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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