| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADZ08450.1 | ADZ08787.1 | Metbo_0198 | Metbo_0535 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | 0.610 |
| ADZ08450.1 | ADZ08943.1 | Metbo_0198 | Metbo_0692 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. | 0.422 |
| ADZ08450.1 | ADZ09402.1 | Metbo_0198 | Metbo_1158 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; KEGG: mmg:MTBMA_c08270 ATPase; TIGRFAM: Conserved hypothetical protein CHP03679, ATP-binding; Conserved hypothetical protein CHP00289; Domain of unknown function DUF71, ATP-binding domain; PFAM: Domain of unknown function DUF71, ATP-binding domain. | 0.678 |
| ADZ08450.1 | ADZ10146.1 | Metbo_0198 | Metbo_1926 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: mst:Msp_0372 histone acetyltransferase; PFAM: Radical SAM; GCN5-related N-acetyltransferase (GNAT) domain. | 0.629 |
| ADZ08450.1 | dphB | Metbo_0198 | Metbo_0693 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.941 |
| ADZ08450.1 | eif2b | Metbo_0198 | Metbo_0528 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.668 |
| ADZ08450.1 | fusA | Metbo_0198 | Metbo_2390 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.986 |
| ADZ08450.1 | rpl37ae | Metbo_0198 | Metbo_2183 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.632 |
| ADZ08450.1 | rps4e | Metbo_0198 | Metbo_0787 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | HAMAP: Ribosomal protein S4e, archaea; PFAM: Ribosomal protein S4e, central; Ribosomal protein S4e, N-terminal; RNA-binding S4; KEGG: mmg:MTBMA_c05040 30S ribosomal protein S4e; SMART: RNA-binding S4; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.647 |
| ADZ08787.1 | ADZ08450.1 | Metbo_0535 | Metbo_0198 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.610 |
| ADZ08787.1 | ADZ10146.1 | Metbo_0535 | Metbo_1926 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: mst:Msp_0372 histone acetyltransferase; PFAM: Radical SAM; GCN5-related N-acetyltransferase (GNAT) domain. | 0.576 |
| ADZ08787.1 | dphB | Metbo_0535 | Metbo_0693 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.698 |
| ADZ08787.1 | eif2b | Metbo_0535 | Metbo_0528 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.728 |
| ADZ08787.1 | fusA | Metbo_0535 | Metbo_2390 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.535 |
| ADZ08787.1 | rpl37ae | Metbo_0535 | Metbo_2183 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.635 |
| ADZ08787.1 | rps4e | Metbo_0535 | Metbo_0787 | Small GTP-binding protein; KEGG: mth:MTH1621 GTP1/OBG family GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | HAMAP: Ribosomal protein S4e, archaea; PFAM: Ribosomal protein S4e, central; Ribosomal protein S4e, N-terminal; RNA-binding S4; KEGG: mmg:MTBMA_c05040 30S ribosomal protein S4e; SMART: RNA-binding S4; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.831 |
| ADZ08943.1 | ADZ08450.1 | Metbo_0692 | Metbo_0198 | PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.422 |
| ADZ08943.1 | ADZ08945.1 | Metbo_0692 | Metbo_0694 | PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. | DNA adenine methylase; Manually curated; TIGRFAM: D12 class N6 adenine-specific DNA methyltransferase; KEGG: tit:Thit_0485 DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. | 0.528 |
| ADZ08943.1 | ADZ10146.1 | Metbo_0692 | Metbo_1926 | PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. | Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: mst:Msp_0372 histone acetyltransferase; PFAM: Radical SAM; GCN5-related N-acetyltransferase (GNAT) domain. | 0.727 |
| ADZ08943.1 | dphB | Metbo_0692 | Metbo_0693 | PFAM: Protein of unknown function Met10; KEGG: mfv:Mfer_1183 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.865 |
