Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ08999.1KEGG: mmg:MTBMA_c11120 tetratricopeptide repeat domain-containing protein; PFAM: Tetratricopeptide TPR-1; Tetratricopeptide TPR2; SMART: Tetratricopeptide repeat. (158 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein dnaK; Acts as a chaperone.
  
 0.778
ADZ08374.1
PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; KEGG: rci:RCIX757 peptidyl-prolyl cis-trans isomerase B (cyclophilin type).
 
 0.765
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.758
rpoH
DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
  
 0.748
rpoD
DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 0.733
ADZ10283.1
SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2.
  
 0.729
rpoK
DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
 
 0.727
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.721
ADZ09712.1
Heat shock protein DnaJ domain protein; KEGG: pfh:PFHG_00645 hypothetical protein similar to chaperone protein J; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal.
  
 0.721
ADZ10397.1
RNA polymerase Rbp10; KEGG: mmg:MTBMA_c10670 DNA-directed RNA polymerase II, subunit RPC10; manually curated; SMART: RNA polymerase Rbp10.
  
 0.711
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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