Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADZ09011.1TIGRFAM: Pyridoxal phosphate-dependent transferase, archaea; KEGG: msi:Msm_0767 selenocysteine synthase, SelA. (386 aa)    
Predicted Functional Partners:
serS
Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
    
 0.940
ADZ10143.1
PFAM: Protein of unknown function DUF2098; KEGG: mth:MTH814 hypothetical protein.
  
    0.931
ADZ09010.1
Protein of unknown function DUF88; KEGG: mmg:MTBMA_c04840 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00288; PFAM: Domain of unknown function DUF88.
   
   0.801
ADZ10736.1
PFAM: HTH transcriptional regulator, LysR; KEGG: mru:mru_0249 transcriptional regulator LysR family.
 
   
 0.749
ADZ08727.1
PFAM: PhoU; KEGG: mmg:MTBMA_c03000 phosphate transport system regulator.
  
     0.728
ADZ08846.1
PFAM: tRNA-specific 2-thiouridylase; KEGG: mru:mru_1475 hypothetical protein.
  
     0.714
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
       0.697
ADZ10454.1
Protein of unknown function DUF129; PFAM: F420-0 gamma-glutamyl ligase-related; KEGG: mth:MTH1670 hypothetical protein.
  
     0.668
ADZ08786.1
PFAM: Oligosaccharyl transferase, STT3 subunit; KEGG: mmg:MTBMA_c02090 oligosaccharyl transferase STT3 subunit related protein.
  
     0.640
ADZ08626.1
Protein of unknown function DUF795; PFAM: Uncharacterised protein family UPF0348; KEGG: mmg:MTBMA_c15090 nucleotidyltransferase.
  
     0.639
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.