Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
ADZ09087.1PFAM: Protein of unknown function DUF166; 4Fe-4S binding domain; KEGG: mmp:MMP0986 thymidylate synthase. (313 aa)    
Predicted Functional Partners:
cdhA
Acetyl-CoA decarbonylase/synthase complex subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
 
     0.627
cdhB
Acetyl-CoA decarbonylase/synthase complex subunit epsilon; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family.
 
     0.611
ADZ09086.1
Precorrin-4 C11-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase, core; KEGG: msi:Msm_0101 precorrin-3 methylase, CbiF; PFAM: Tetrapyrrole methylase.
       0.603
cdhD
CO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.
 
     0.582
ADZ08772.1
PFAM: Thymidylate kinase; KEGG: mmg:MTBMA_c14850 thymidylate kinase-related protein.
    
  0.519
tmk
PFAM: Thymidylate kinase; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: msi:Msm_0520 thymidylate kinase, Tmk.
    
  0.519
ADZ08320.1
PFAM: Protein of unknown function DUF63; KEGG: mth:MTH1480 hypothetical protein.
  
     0.509
ADZ08803.1
dUTP diphosphatase; KEGG: msi:Msm_0687 deoxycytidine-triphosphate deaminase, dcd; PFAM: DeoxyUTP pyrophosphatase domain.
     
  0.500
ADZ09088.1
Response regulator receiver protein; KEGG: mth:MTH374 dolichyl-phosphate mannose synthase related protein; PFAM: Glycosyl transferase, family 2; Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain.
       0.497
cdhC
CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.
 
     0.496
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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