Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ09239.1PFAM: Cytidylyltransferase; TIGRFAM: Nicotinamide-nucleotide adenylyltransferase, archaeal type; Cytidyltransferase-related; HAMAP: Nicotinamide-nucleotide adenylyltransferase, archaeal type; KEGG: mmg:MTBMA_c06000 nicotinamide-nucleotide adenylyltransferase. (174 aa)    
Predicted Functional Partners:
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.962
ADZ08897.1
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
    
 0.956
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.924
ADZ09930.1
NAD(+) diphosphatase; KEGG: cce:Ccel_2937 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; NADH pyrophosphatase-like, N-terminal; Zinc ribbon, NADH pyrophosphatase.
     
 0.902
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
ADZ09237.1
KEGG: mth:MTH148 hypothetical protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain.
  
    0.864
ADZ09238.1
PFAM: Molybdopterin biosynthesis MoaE; KEGG: mru:mru_1268 molybdenum cofactor biosynthesis protein MoaE.
       0.848
ADZ08637.1
tRNA ribose 2'-O-methyltransferase aTrm56; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
 
     0.808
tiaS
Domain of unknown function DUF1743; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
  
     0.651
ADZ08298.1
Protein of unknown function DUF120; PFAM: Riboflavin kinase, CTP-dependent, archaeal; KEGG: mru:mru_2174 riboflavin kinase RibK.
 
   
 0.621
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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