STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ09258.1TIGRFAM: Phosphomethylpyrimidine kinase type-2; KEGG: mfv:Mfer_1038 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (250 aa)    
Predicted Functional Partners:
ADZ10179.1
PFAM: Phosphomethylpyrimidine kinase; Histidine triad (HIT) protein; KEGG: mmg:MTBMA_c12580 phosphomethylpyrimidine kinase.
  
 0.992
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.983
ADZ10738.1
Phosphomethylpyrimidine synthase; TIGRFAM: Thiamine biosynthesis protein ThiC; HAMAP: Thiamine biosynthesis protein ThiC; KEGG: mth:MTH1543 thiamine biosynthesis protein ThiC; PFAM: Thiamine biosynthesis protein ThiC.
 
 
 0.983
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
       0.934
proS
Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
  
  
 0.854
ADZ09260.1
KEGG: mth:MTH612 hypothetical protein.
       0.763
ADZ08745.1
PFAM: ThiamineS; KEGG: mru:mru_0563 thiamine biosynthesis protein ThiS.
  
    0.731
ADZ09509.1
Hypothetical protein.
  
    0.731
thi4-2
Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
  
 0.727
thi4
Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
  
 0.716
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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