STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ09328.1Porphobilinogen synthase; KEGG: mru:mru_1560 delta-aminolevulinic acid dehydratase HemB; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family. (323 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
 0.996
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; KEGG: mfv:Mfer_0593 glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
 
 0.991
ADZ10337.1
KEGG: mfv:Mfer_1298 uroporphyrinogen III synthase HEM4; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
 
 
 0.936
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.826
ADZ10336.1
TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: mru:mru_1541 uroporphyrin-III C-methyltransferase CobA; PFAM: Tetrapyrrole methylase.
 
  
 0.802
ADZ09327.1
PFAM: Triphosphoribosyl-dephospho-CoA protein; KEGG: mfv:Mfer_1255 triphosphoribosyl-dephospho-CoA protein.
       0.765
pheS
TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 2, bacterial/archaeal; KEGG: mmg:MTBMA_c11370 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  
    0.665
ADZ09272.1
Methyltransferase MtaA/CmuA family; KEGG: msi:Msm_0518 methylcobalamin:coenzyme M methyltransferase, MtaA; TIGRFAM: Methyltransferase MtaA/CmuA; PFAM: Uroporphyrinogen decarboxylase (URO-D).
  
 
 0.619
ADZ08370.1
precorrin-3B C17-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; KEGG: mfv:Mfer_1185 precorrin-3 methyltransferase; PFAM: Cysteine-rich small domain; Tetrapyrrole methylase.
     
 0.609
cysS
SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: mst:Msp_0124 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family.
     
 0.583
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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