Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ10291.1Adenylyl cyclase CyaB; KEGG: mmg:MTBMA_c02140 adenylate cyclase; TIGRFAM: Adenylyl cyclase CyaB; PFAM: Adenylate cyclase. (180 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
 
  
  0.917
ADZ09363.1
RelA/SpoT domain protein; KEGG: pfs:PFLU1597 hypothetical protein; PFAM: RelA/SpoT; SMART: RelA/SpoT.
     
  0.900
ADZ10744.1
TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; KEGG: mmg:MTBMA_c01230 anaerobic ribonucleotide-triphosphate reductase; PFAM: ATP-cone.
     
  0.900
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.815
mptA
Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
    
  0.805
gch3
GTP cyclohydrolase III; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
     
  0.800
ADZ10292.1
KEGG: mth:MTH1628 hypothetical protein.
       0.746
mat
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
 
     0.698
ADZ09618.1
UPF0219 protein; TIGRFAM: Putative condensing enzyme FabH-related; HAMAP: Putative condensing enzyme FabH-related; KEGG: mmg:MTBMA_c11880 3-hydroxy-3-methylglutaryl-CoA-synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; Hydroxymethylglutaryl-coenzyme A synthase, N-terminal; Belongs to the thiolase-like superfamily. UPF0219 family.
 
   
 0.623
ADZ08434.1
PFAM: Domain of unknown function DUF35, OB-fold, C-terminal; KEGG: mmg:MTBMA_c17840 nucleic acid-binding protein.
 
     0.597
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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