STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10309.1PFAM: Protein of unknown function DUF371; KEGG: mfv:Mfer_0382 hypothetical protein. (137 aa)    
Predicted Functional Partners:
tfe-2
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
   
 0.663
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
   
 0.646
ADZ10311.1
KEGG: mst:Msp_1119 hypothetical protein; PFAM: Protein of unknown function DUF123; SMART: Excinuclease ABC, C subunit, N-terminal.
 
     0.627
comB
PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulpholactate phosphatase; HAMAP: 2-phosphosulpholactate phosphatase ComB; KEGG: mfv:Mfer_1236 2-phosphosulfolactate phosphatase.
   
    0.623
ADZ10454.1
Protein of unknown function DUF129; PFAM: F420-0 gamma-glutamyl ligase-related; KEGG: mth:MTH1670 hypothetical protein.
  
    0.586
ADZ10310.1
KEGG: dae:Dtox_1747 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like.
 
     0.568
ADZ09051.1
PFAM: Protein of unknown function DUF106, transmembrane; KEGG: mmg:MTBMA_c05170 hypothetical protein.
  
     0.553
gch3
GTP cyclohydrolase III; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
  
     0.520
ADZ10341.1
GHMP kinase; KEGG: mst:Msp_1187 kinase; manually curated; PFAM: GHMP kinase.
  
     0.504
ADZ08555.1
KEGG: mmg:MTBMA_c16020 transcription elongation factor NusA-like protein.
  
     0.493
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: medium (70%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.