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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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gene co-occurrence
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Score
ADZ10336.1TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: mru:mru_1541 uroporphyrin-III C-methyltransferase CobA; PFAM: Tetrapyrrole methylase. (243 aa)    
Predicted Functional Partners:
ADZ10337.1
KEGG: mfv:Mfer_1298 uroporphyrinogen III synthase HEM4; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
  
 0.996
ADZ10654.1
TIGRFAM: Sirohaem synthase, N-terminal; KEGG: msi:Msm_0968 bifunctional precorrin-2 oxidase/chelatase (siroheme synthase), CysG.
 
 
 0.995
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.990
ADZ08388.1
Precorrin-2 C20-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase, core; KEGG: mst:Msp_0038 CbiL; PFAM: Tetrapyrrole methylase.
 
 
0.952
ADZ09328.1
Porphobilinogen synthase; KEGG: mru:mru_1560 delta-aminolevulinic acid dehydratase HemB; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family.
 
  
 0.885
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.871
ADZ08370.1
precorrin-3B C17-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; KEGG: mfv:Mfer_1185 precorrin-3 methyltransferase; PFAM: Cysteine-rich small domain; Tetrapyrrole methylase.
 
 
0.862
srp19
Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
       0.852
purQ
Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
     
 0.822
purS
Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...]
       0.819
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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