Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10392.1PFAM: Histidine biosynthesis; KEGG: mru:mru_1337 HisA/HisF family protein HisAF; Belongs to the HisA/HisF family. (223 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.929
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: mmg:MTBMA_c12400 phosphoribosylformimino-5-aminoimidazole ribonucleotide isomerase.
  
  
0.928
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
  0.916
ADZ10391.1
PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: mst:Msp_1258 ribokinase.
       0.915
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
     
  0.900
mfnB
UPF0264 protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.787
ADZ10168.1
H4MPT-linked C1 transfer pathway protein; KEGG: mth:MTH834 hypothetical protein; TIGRFAM: Tetrahydromethanopterin-linked C1 transfer pathway, putative; PFAM: Hydantoinase/oxoprolinase.
 
   
 0.709
ADZ10722.1
KEGG: mru:mru_0344 tungsten formylmethanofuran dehydrogenase subunit A FwdA; TIGRFAM: Formylmethanofuran dehydrogenase, subunit A; PFAM: Amidohydrolase 3.
 
   
 0.700
ADZ10169.1
PFAM: ATP-grasp fold, DUF201-type; KEGG: mmg:MTBMA_c12330 ATP-utilizing enzyme.
 
     0.696
ADZ08657.1
PFAM: Aspartate/glutamate/uridylate kinase; KEGG: mfv:Mfer_0582 aspartate/glutamate/uridylate kinase.
 
   
 0.666
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.