| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADZ08380.1 | ADZ10283.1 | Metbo_0127 | Metbo_2064 | KEGG: mst:Msp_0033 hypothetical protein. | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | 0.771 |
| ADZ08380.1 | pan | Metbo_0127 | Metbo_2222 | KEGG: mst:Msp_0033 hypothetical protein. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.910 |
| ADZ08380.1 | pfdB | Metbo_0127 | Metbo_2179 | KEGG: mst:Msp_0033 hypothetical protein. | Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.412 |
| ADZ08380.1 | psmA | Metbo_0127 | Metbo_2188 | KEGG: mst:Msp_0033 hypothetical protein. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.857 |
| ADZ10283.1 | ADZ08380.1 | Metbo_2064 | Metbo_0127 | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | KEGG: mst:Msp_0033 hypothetical protein. | 0.771 |
| ADZ10283.1 | pan | Metbo_2064 | Metbo_2222 | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.777 |
| ADZ10283.1 | psmA | Metbo_2064 | Metbo_2188 | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.831 |
| ADZ10283.1 | psmB | Metbo_2064 | Metbo_0323 | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.805 |
| ADZ10283.1 | rpl15e | Metbo_2064 | Metbo_2192 | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | KEGG: mmg:MTBMA_c10770 50S ribosomal protein L15e; HAMAP: Ribosomal protein L15e, archaeal; PFAM: Ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.536 |
| ADZ10401.1 | pfdB | Metbo_2187 | Metbo_2179 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.835 |
| ADZ10401.1 | psmA | Metbo_2187 | Metbo_2188 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.953 |
| ADZ10401.1 | rnp2 | Metbo_2187 | Metbo_2189 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | Ribonuclease P protein component 2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | 0.798 |
| ADZ10401.1 | rpl15e | Metbo_2187 | Metbo_2192 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | KEGG: mmg:MTBMA_c10770 50S ribosomal protein L15e; HAMAP: Ribosomal protein L15e, archaeal; PFAM: Ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.958 |
| ADZ10401.1 | rpl37ae | Metbo_2187 | Metbo_2183 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.979 |
| ADZ10401.1 | rrp42 | Metbo_2187 | Metbo_2184 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mth:MTH685 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, N-terminal; Ribosome maturation protein SBDS, C-terminal. | 3' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. | 0.788 |
| pan | ADZ08380.1 | Metbo_2222 | Metbo_0127 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | KEGG: mst:Msp_0033 hypothetical protein. | 0.910 |
| pan | ADZ10283.1 | Metbo_2222 | Metbo_2064 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. | 0.777 |
| pan | psmA | Metbo_2222 | Metbo_2188 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.945 |
| pan | psmB | Metbo_2222 | Metbo_0323 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.961 |
| pan | rpl15e | Metbo_2222 | Metbo_2192 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | KEGG: mmg:MTBMA_c10770 50S ribosomal protein L15e; HAMAP: Ribosomal protein L15e, archaeal; PFAM: Ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.407 |
