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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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thyAThymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (205 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
  
 
 0.932
tmk
PFAM: Thymidylate kinase; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: msi:Msm_0520 thymidylate kinase, Tmk.
  
 
 0.932
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
  
 
 0.932
ADZ08772.1
PFAM: Thymidylate kinase; KEGG: mmg:MTBMA_c14850 thymidylate kinase-related protein.
  
 
 0.930
ADZ08803.1
dUTP diphosphatase; KEGG: msi:Msm_0687 deoxycytidine-triphosphate deaminase, dcd; PFAM: DeoxyUTP pyrophosphatase domain.
  
 
 0.927
ADZ10270.1
KEGG: mst:Msp_1077 dihydrolipoamide dehydrogenase-related protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.922
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
 
 0.921
ADZ10411.1
PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mth:MTH775 methionine synthase.
     
 0.918
ADZ09232.1
KEGG: mfv:Mfer_0255 thymidylate synthase, methanogen type.
  
  
 
0.905
ADZ10412.1
PFAM: Uncharacterised conserved protein UCP006577; KEGG: mru:mru_1621 hypothetical protein.
 
     0.826
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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