STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10420.1TIGRFAM: Peptidase S16, archaeal lon homologues; PFAM: Peptidase S16, Lon C-terminal; ATPase, AAA-5; KEGG: mth:MTH785 ATP-dependent protease Lon; SMART: ATPase, AAA+ type, core; Belongs to the peptidase S16 family. (638 aa)    
Predicted Functional Partners:
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 
 0.751
dnaK
Chaperone protein dnaK; Acts as a chaperone.
 
  
 0.698
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
  
 0.683
rpl40e
HAMAP: 50S ribosomal protein L40e; KEGG: mmg:MTBMA_c09420 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
  
  0.681
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
 
 
 0.659
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.650
ADZ09610.1
Thermosome; KEGG: mmg:MTBMA_c06670 thermosome, subunit alpha (chaperonin subunit); TIGRFAM: Thermosome, archaeal; PFAM: Chaperonin Cpn60/TCP-1.
 
  
 0.647
ADZ10121.1
Thermosome; KEGG: mth:MTH794 chaperonin; TIGRFAM: Thermosome, archaeal; PFAM: Chaperonin Cpn60/TCP-1.
 
  
 0.646
ADZ08756.1
TIGRFAM: Conserved hypothetical protein CHP01210; PFAM: Radical SAM; KEGG: mmg:MTBMA_c03260 Fe-S oxidoreductase; SMART: Elongator protein 3/MiaB/NifB.
  
     0.615
ADZ08463.1
TIGRFAM: Conserved hypothetical protein CHP00062; KEGG: mmg:MTBMA_c16920 hypothetical protein.
  
     0.574
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.