STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (410 aa)    
Predicted Functional Partners:
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.990
rad50
SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
   
 
 0.987
rpl40e
HAMAP: 50S ribosomal protein L40e; KEGG: mmg:MTBMA_c09420 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.977
ADZ10053.1
PFAM: Peptidase S1/S6, chymotrypsin/Hap; KEGG: drm:Dred_0467 peptidase S1 and S6, chymotrypsin/Hap.
  
 0.976
ADZ08673.1
Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; KEGG: mmg:MTBMA_c13570 hypothetical protein.
  
 0.975
ADZ09355.1
KEGG: cte:CT1466 TIR domain-containing protein; PFAM: Toll-Interleukin receptor; SMART: Toll-Interleukin receptor.
  
 0.975
psmB
Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.974
ADZ08380.1
KEGG: mst:Msp_0033 hypothetical protein.
  
 0.940
ADZ10283.1
SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2.
 
0.817
ADZ09791.1
SMC domain protein; PFAM: RecF/RecN/SMC; KEGG: rlg:Rleg_1580 SMC domain protein.
   
 
 0.751
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.