Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10452.1Metal dependent phosphohydrolase; TIGRFAM: HD-related protein; Uncharacterised protein family HDIG; PFAM: Metal-dependent phosphohydrolase, HD subdomain; KEGG: mru:mru_0474 HD domain-containing protein; SMART: Metal-dependent phosphohydrolase, HD domain. (169 aa)    
Predicted Functional Partners:
ADZ08637.1
tRNA ribose 2'-O-methyltransferase aTrm56; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
     0.950
tfe-2
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
       0.687
ADZ09975.1
Nitrite reductase (NAD(P)H); KEGG: mba:Mbar_A3664 hypothetical protein; PFAM: Nitrite/sulphite reductase 4Fe-4S domain; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like.
 
  
 0.590
rps27ae
KEGG: mst:Msp_0620 30S ribosomal protein S27ae; HAMAP: Ribosomal protein S27ae; PFAM: Ribosomal protein S27a; Belongs to the eukaryotic ribosomal protein eS31 family.
  
     0.546
ADZ08696.1
PFAM: ATP-grasp fold, DUF201-type; KEGG: mfv:Mfer_0930 hypothetical protein.
       0.541
ADZ10454.1
Protein of unknown function DUF129; PFAM: F420-0 gamma-glutamyl ligase-related; KEGG: mth:MTH1670 hypothetical protein.
 
    0.529
rps15
PFAM: Ribosomal protein S15; Ribosomal protein S13/S15, N-terminal; KEGG: mmg:MTBMA_c00110 30S ribosomal protein S15P.
  
  
 0.480
ADZ10542.1
ATPase associated with various cellular activities AAA_5; KEGG: mth:MTH892 ATP-dependent protease La related protein; PFAM: ATPase, AAA-5; SMART: ATPase, AAA+ type, core.
 
   
 0.460
ADZ10544.1
HAMAP: Uncharacterised protein family UPF0292; PFAM: Toprim domain; KEGG: mth:MTH890 hypothetical protein; SMART: Toprim domain.
 
   
 0.445
psmB
Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
     0.437
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.