Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ10478.1KEGG: mfv:Mfer_0340 mur ligase middle domain protein; PFAM: Mur ligase, central; Mur ligase, C-terminal. (407 aa)    
Predicted Functional Partners:
purQ
Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
     
  0.900
ADZ10479.1
KEGG: mmg:MTBMA_c09170 hypothetical protein.
       0.728
ADZ10431.1
Mur ligase middle domain protein; PFAM: Mur ligase, central; Mur ligase, C-terminal; KEGG: msi:Msm_1190 UDP-N-acetylmuramate-alanine ligase.
 
     0.723
ADZ10428.1
KEGG: mth:MTH735 phospho-N-acetylmuramoyl-pentapeptide-transferase; PFAM: Glycosyl transferase, family 4; Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site.
  
     0.721
ADZ10429.1
Mur ligase middle domain protein; PFAM: Mur ligase, central; Mur ligase, C-terminal; KEGG: mfv:Mfer_0762 mur ligase middle domain protein.
  
     0.683
ADZ10480.1
PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: msi:Msm_0116 MobA-related protein.
 
     0.624
ADZ09210.1
KEGG: mmg:MTBMA_c06320 hypothetical protein.
  
     0.571
ADZ08727.1
PFAM: PhoU; KEGG: mmg:MTBMA_c03000 phosphate transport system regulator.
  
     0.551
ADZ08841.1
KEGG: mmg:MTBMA_c02720 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII.
  
     0.551
ADZ10278.1
KEGG: mfv:Mfer_0066 cell wall biosynthesis protein.
  
     0.549
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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