STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10578.1TIGRFAM: Conserved hypothetical protein CHP01177; PFAM: Putative RNA methylase; THUMP; KEGG: mfv:Mfer_0515 RNA methylase; SMART: THUMP. (351 aa)    
Predicted Functional Partners:
ADZ10579.1
Geranylgeranyl reductase; KEGG: mth:MTH725 hypothetical protein; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
    0.926
ADZ10575.1
KEGG: mru:mru_1415 hypothetical protein.
 
     0.816
cimA
Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
    0.813
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
  
 0.705
tgtA
7-cyano-7-deazaguanine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
  
 0.687
ADZ08361.1
tRNA (adenine-N(1)-)-methyltransferase; Manually curated; KEGG: mth:MTH1414 protein-L-isoaspartate methyltransferase-like protein; PFAM: Protein-L-isoaspartate(D-aspartate) O-methyltransferase.
   
  
 0.658
trm1
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
 
 0.642
ADZ08452.1
PFAM: DNA-directed RNA polymerase, dimerisation; KEGG: mth:MTH1317 DNA-dependent RNA polymerase, subunit L.
 
    0.639
ADZ08932.1
SMART: Nucleotide binding protein, PINc; KEGG: mru:mru_1781 hypothetical protein.
  
    0.633
ADZ10396.1
Brix domain protein; Probably involved in the biogenesis of the ribosome.
  
    0.624
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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