Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ10578.1TIGRFAM: Conserved hypothetical protein CHP01177; PFAM: Putative RNA methylase; THUMP; KEGG: mfv:Mfer_0515 RNA methylase; SMART: THUMP. (351 aa)    
Predicted Functional Partners:
ADZ10579.1
Geranylgeranyl reductase; KEGG: mth:MTH725 hypothetical protein; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
    0.927
ADZ10575.1
KEGG: mru:mru_1415 hypothetical protein.
 
     0.858
cimA
Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
    0.836
ADZ08440.1
Methylase; KEGG: mmg:MTBMA_c17150 methyltransferase; TIGRFAM: Putative methylase; PFAM: Methyltransferase small.
  
 
 
 0.834
trm1
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
 
 0.758
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
  
 0.714
ADZ08452.1
PFAM: DNA-directed RNA polymerase, dimerisation; KEGG: mth:MTH1317 DNA-dependent RNA polymerase, subunit L.
 
    0.699
ADZ08932.1
SMART: Nucleotide binding protein, PINc; KEGG: mru:mru_1781 hypothetical protein.
  
    0.649
ADZ10396.1
Brix domain protein; Probably involved in the biogenesis of the ribosome.
  
    0.631
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
     0.622
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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