STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10662.1TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: mmg:MTBMA_c06610 DNA lyase; PFAM: Endonuclease/exonuclease/phosphatase. (257 aa)    
Predicted Functional Partners:
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.999
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.994
ADZ09658.1
PHP domain protein; KEGG: mmg:MTBMA_c09400 DNA polymerase IV; PFAM: PHP, C-terminal; SMART: DNA-directed DNA polymerase X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal.
    
 0.985
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.984
ADZ10658.1
KEGG: msi:Msm_0963 endonuclease IV; PFAM: Xylose isomerase, TIM barrel domain; SMART: Endodeoxyribonuclease IV.
   
 
 0.949
ADZ10320.1
snRNP Sm-like protein; SMART: Like-Sm ribonucleoprotein (LSM) domain, eukaryotic/archaea-type; manually curated; HAMAP: snRNP Sm-like, putative, archaea; KEGG: mst:Msp_1175 small nuclear ribonucleoprotein; PFAM: Like-Sm ribonucleoprotein (LSM) domain; Belongs to the snRNP Sm proteins family.
   
 0.938
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 
 0.901
ADZ10598.1
PFAM: DNA ligase, ATP-dependent, central; DNA ligase, ATP-dependent, C-terminal; KEGG: afu:AF1725 DNA ligase, putative.
  
 
 0.837
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 
 0.837
ADZ08381.1
PFAM: Methylpurine-DNA glycosylase (MPG); TIGRFAM: Methylpurine-DNA glycosylase (MPG); HAMAP: Methylpurine-DNA glycosylase (MPG); KEGG: ccb:Clocel_1348 DNA-3-methyladenine glycosylase; Belongs to the DNA glycosylase MPG family.
    
 0.816
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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