Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADZ10665.1PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: mmp:MMP1271 2-oxoisovalerate oxidoreductase subunit alpha. (481 aa)    
Predicted Functional Partners:
ADZ10666.1
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: mmp:MMP1272 2-ketoisovalerate ferredoxin reductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal.
 
 0.999
ADZ10667.1
PFAM: 4Fe-4S binding domain; KEGG: mmq:MmarC5_0318 ketoisovalerate ferredoxin oxidoreductase, delta subunit.
 
 
 0.999
ADZ10621.1
KEGG: mmg:MTBMA_c14150 2-oxoglutarate synthase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal.
 
 
 0.950
ADZ10270.1
KEGG: mst:Msp_1077 dihydrolipoamide dehydrogenase-related protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
    
 0.916
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.915
ADZ10663.1
TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: mmg:MTBMA_c09240 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
 
 
0.905
ADZ10668.1
Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase.
 
  
 0.891
ADZ10664.1
TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: mmg:MTBMA_c09230 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain.
 
 
 0.861
ADZ10669.1
KEGG: mmz:MmarC7_0521 cupin 2 domain-containing protein; PFAM: Cupin 2, conserved barrel; Helix-turn-helix type 3; SMART: Helix-turn-helix type 3.
 
  
 0.854
ADZ10620.1
KEGG: mth:MTH1034 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
 
 
0.847
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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