STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fdhDProtein fdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (250 aa)    
Predicted Functional Partners:
mobA
Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
 
 
 0.949
ADZ10716.1
Putative transcriptional regulator, ModE family; PFAM: Transport-associated OB, type 1; HTH transcriptional regulator, LysR; KEGG: msi:Msm_1207 molybdate transport system regulatory protein.
 
   
 0.910
ADZ10728.1
TIGRFAM: Formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S binding domain; Molydopterin dinucleotide-binding domain; KEGG: mth:MTH1552 formate dehydrogenase, alpha subunit-like protein; SMART: Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding.
 
  
 0.835
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
 0.786
ADZ10070.1
KEGG: mma:MM_1955 cysteine desulfurase NifS; PFAM: Aminotransferase, class V/Cysteine desulfurase.
  
 0.786
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
 
  
 0.778
ADZ10731.1
NADH dehydrogenase (quinone); PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S binding domain; KEGG: mth:MTH1549 NADP-reducing hydrogenase, subunit C; SMART: NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding.
  
  
 0.728
ADZ10732.1
PFAM: NADH:ubiquinone oxidoreductase, 24kDa subunit; KEGG: mth:MTH1548 NADH dehydrogenase subunit E.
     
 0.648
ADZ10729.1
KEGG: tpd:Teth39_0854 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB), conserved domain; PFAM: Putative Fe-S cluster.
 
  
 0.638
moaC
Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
 
  
 0.624
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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