STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ10738.1Phosphomethylpyrimidine synthase; TIGRFAM: Thiamine biosynthesis protein ThiC; HAMAP: Thiamine biosynthesis protein ThiC; KEGG: mth:MTH1543 thiamine biosynthesis protein ThiC; PFAM: Thiamine biosynthesis protein ThiC. (429 aa)    
Predicted Functional Partners:
ADZ09258.1
TIGRFAM: Phosphomethylpyrimidine kinase type-2; KEGG: mfv:Mfer_1038 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 
 0.983
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 
0.903
purM
TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: msi:Msm_1039 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal.
    
 0.826
ADZ08745.1
PFAM: ThiamineS; KEGG: mru:mru_0563 thiamine biosynthesis protein ThiS.
  
  
 0.667
ADZ09509.1
Hypothetical protein.
  
  
 0.667
lysS
PFAM: Lysyl-tRNA synthetase, class Ic; TIGRFAM: Lysyl-tRNA synthetase, class I; HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; KEGG: mth:MTH1542 hypothetical protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.667
cofH
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 0.653
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
  
 0.653
cofH-2
FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 0.653
ADZ09451.1
PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: mbn:Mboo_1985 UBA/ThiF-type NAD/FAD binding protein.
  
  
 0.642
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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